TRNA-dihydrouridine16/17 synthase (NAD(P)+) (EC 1.3.1.88, Dus1p, tRNA-dihydrouridine synthase 1) is an enzyme with systematic name tRNA-5,6-dihydrouracil16/17:NAD(P)+ oxidoreductase. This enzyme catalyses the following chemical reaction

(1) 5,6-dihydrouracil16 in tRNA + NAD(P)+



⇌


{\displaystyle \rightleftharpoons }

uracil16 in tRNA + NAD(P)H + H+
(2) 5,6-dihydrouracil17 in tRNA + NAD(P)+



⇌


{\displaystyle \rightleftharpoons }

uracil17 in tRNA + NAD(P)H + H+
This enzyme specifically modifies uracil16 and uracil17 in tRNA.

References

External links
TRNA-dihydrouridine16/17+synthase+(NAD(P)+) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)