SpaceX CRS-35, also known as SpX-35, is an International Space Station (ISS) cargo resupply mission contracted by NASA and operated by SpaceX. The flight launched on October 13, 2026 from Space Launch Complex 40 at Cape Canaveral Space Force Station. It is SpaceX's 35th cargo delivery mission under the Commercial Resupply Services program.
Manifest
The Cargo Dragon spacecraft was loaded with a total of 6,322 lb (2,868 kg) of cargo and supplies before its launch, including 3,687 lb (1,672 kg) of pressurized and 2,635 lb (1,195 kg) of unpressurized cargo.
The cargo manifest includes:
Crew supplies: 844 lb (383 kg)
Science investigations: 1,307 lb (593 kg)
Spacewalk equipment: 417 lb (189 kg)
Vehicle hardware: 799 lb (362 kg)
Computer resources 81 lb (36 kg)
Research
A variety of experiements will be transported to the ISS, providing insight for researchers and the broader scientific community.
CRS-35 carried replacement ISS Roll Out Solar Arrays. The mission also carried a payload designed by Langston University.
LambdaVision-1
LambdaVision-1 investigates the production of artificial retinal tissue in microgravity. Researchers are studying whether depositing the tissue in successive thin layers in microgravity can produce more uniform and stable material. The research could contribute to the development of artificial retinas for patients with retinal diseases.
Stellar Spheroids
Stellar Spheroids studies the growth and function of three-dimensional human heart-tissue models in microgravity. Researchers are examining whether the space environment promotes the formation of vascular networks within the tissue. The findings could help improve models used to study cardiovascular disease and evaluate the effects of drugs on heart function.
ELF-Unconventional Glass 2
ELF-Unconventional Glass 2 investigates how glass made from non-traditional elements forms in microgravity. Researchers will observe the behavior of molten glass in space and analyze the resulting samples after their return to Earth. The work could inform the development of glasses with improved mechanical, optical, or durability properties for use in spacecraft and other technologies.
MINDS
The MINDS investigation studies brain organoids to investigate neuroinflammation associated with neurodegenerative diseases. Its experimental approach includes combining cells from multiple individuals into organoid models, allowing researchers to examine biological responses across a more diverse set of cells. The research could help identify potential therapeutic targets for diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis.
AVATAR-Org1
AVATAR-Org1 investigates the effects of spaceflight on human brain tissue using small, laboratory-grown three-dimensional models called miBrains. The models are to remain aboard the ISS for five weeks and are compared with corresponding tissue maintained on Earth. The investigation aims to characterize cellular changes associated with spaceflight and assess whether human brain tissue can be reliably grown and studied in space.
MVP-Plant-02
MVP-Plant-02 investigates whether crop diseases develop more rapidly or become more severe in microgravity. Researchers compare infected plants grown aboard the space station with corresponding plants grown on Earth, examining molecular and structural changes caused by the disease. The findings could inform the development of disease-resistant crops for agriculture on Earth and future space missions.
Commercially Enabled Rapid Space Science
The Commercially Enabled Rapid Space Science initiative includes an evaluation of a compact microplate reader for analyzing biological samples aboard the ISS. The experiment tests the device's ability to measure biomarkers, including antibodies, antigens, and proteins. Rapid onboard analysis could help researchers detect infections and other health issues in astronauts without having to wait for samples to be returned to Earth.
Colorectal cancer organoids
Researchers at the Wake Forest Institute for Regenerative Medicine are using organoids grown from patient-donated colorectal cancer cells to investigate responses to chemotherapy and identify potential targets for new cancer treatments. The research aims to improve models of individual tumors and support the development of more personalized treatment strategies.
Wildfire-related mudflow research
A research project led by the University of California, San Diego, investigates the forces involved in mudflows and debris flows that can occur after wildfires. Experiments in microgravity help researchers examine particle behavior and flow dynamics while reducing the influence of gravity-driven effects that complicate measurements on Earth. The findings could contribute to improved models for predicting these natural hazards.
Genes in Space protein-production experiment
A student-led investigation from the Genes in Space program studies protein production in microgravity. The experiment tests multiple DNA sequences that encode the same protein to determine which sequences support more efficient protein production in space. The results could inform future biological manufacturing applications, including the production of therapeutics and other materials during long-duration space missions.
SCAMPI
CRS-35 also carried three live Halocaridina rubra shrimp as part of the SCAMPI Project, an initiative carried out between 51 students at The Spring Institute for Forests on the Moon, École Polytechnique, ISAE-SUPAERO, IPSA, École d'ingénieurs de PURPAN, Politecnico di Torino, University of Trento, University of Pavia, Utrecht University, TU Delft, Queen Mary University of London, and the University of Arizona.
Student Spaceflight Experiements Program
CRS-35 also carried the Atlantis and Discovery experiments payload for the Student Spaceflight Experiments Program (SSEP), corresponding to Missions 20 and 21 respectively. The investigations cover a range of subjects, including seed germination, crystal growth, cell biology, and materials science. Each community is based on a K-12 school or college/university. Payload includes:
Launch
CRS-35 was originally scheduled to launch in November 2026. However, during the launch of Soyuz MS-28 for the ISS on 27 November 2025, the launch pad at the Baikonur Cosmodrome's Site 31 suffered extensive damage and was rendered inoperable, resulting in an acceleration of future resupply missions. In December 2025, CRS-35's launch was to be accelerated to August 2026. Following the rapid repair of Site 31, CRS-35 was moved back to fall 2026.
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