Phosphoethanolamine/phosphocholine phosphatase (EC 3.1.3.75, PHOSPHO1, 3X11A; systematic name phosphoethanolamine phosphohydrolase) is an enzyme highly expressed in mineralizing cells . This enzyme is implicated in bone and cartilage formation and catalyses the following two chemical reactions:

In each case, a phosphate group is removed by hydrolysis, giving orthophosphate (Pi) as a byproduct. The enzyme is specific for phosphorylethanolamine and phosphocholine.
The enzyme is a member of the haloacid dehalogenase superfamily. Like other members of this superfamily it requires a metal ion for catalysis, which is usually Mg2+, it is also active in the presence of Co2+ or Mn2+ but exhibits a lower specific activity with these metal ions.

References

External links
Phosphoethanolamine/phosphocholine+phosphatase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)